New Syndrome – After Covid-19 Immunization November 22, 2023 Catherine Covid Scandal, Covid19 </p> <h2>New syndrome</h2> <p> Post-Vaccination Syndrome:</p> <p>A Descriptive Analysis of Reported Symptoms and Patient Experiences After Covid-19 Immunization</p> <p>https://www.medrxiv.org/content/10.1101/2023.11.09.23298266v1.full.pdf</p> <p>Yale Listen to Immune, Symptom and Treatment Experiences Now (LISTEN) Study (online)</p> <p>https://medicine.yale.edu/ycci/listen-study/</p> <p>LISTEN study, approved by Yale University Institutional Review Board</p> <p>Introduction</p> <p>A chronic post-vaccination syndrome (PVS) after covid-19 vaccination has been reported but has yet to be well characterized.</p> <p>A chronic syndrome with symptoms that begin soon after vaccination</p> <p>Methods</p> <p>People who joined, May 2022 to July 2023</p> <p>N = 241 individuals, (211 from the US)</p> <p>aged 18 and older,</p> <p>who self-reported PVS after covid-19 vaccination,</p> <p>Deep immune profiling is used for some individuals</p> <p>Results</p> <p>Median age of participants, 46 years</p> <p>Among participants with PVS</p> <p>127 (55%) had received BNT162b2 [Pfizer-BioNTech]</p> <p>86 (37%) received the mRNA-1273 [Moderna]</p> <p>Time from index vaccination to symptom onset</p> <p>Median time, 3 days (IQR: 1 day to 8 days).</p> <p>Time from vaccination to symptom survey completion</p> <p>595 days (IQR: 417 to 661 days)</p> <p>Median Euro-QoL visual analogue scale score was 50 (IQR: 39 to 70).</p> <p>The five most common symptoms</p> <p>Exercise intolerance (71%)</p> <p>Excessive fatigue (69%)</p> <p>Numbness (63%)</p> <p>Brain fog (63%)</p> <p>Neuropathy (63%)</p> <p>In the week before survey completion</p> <p>(Experienced at least once in the week)</p> <p>Feeling unease (93%)</p> <p>Fearfulness (82%)</p> <p>Overwhelmed by worries (81%)</p> <p>Feelings of helplessness (80%)</p> <p>Anxiety (76%)</p> <p>Depression (76%)</p> <p>Hopelessness (72%)</p> <p>Worthlessness (49%)</p> <p>Concerns related to living situations and food security were also prominent.</p> <p>Symptom Severity</p> <p>When asked to quantify symptom severity on their worst days,</p> <p>(0 representing a trivial illness and 100 unbearable condition)</p> <p>Participants reported a median severity of 80</p> <p>Interventions to treat their condition</p> <p>Participants reported a median of 20 (IQR: 13 to 30).</p> <p>Oral steroids, 116 (48% participants)</p> <p>Gabapentin, 61 (25%)</p> <p>Low-dose naltrexone, 48 (20%)</p> <p>I, 44 (18%)</p> <p>Propranolol, 27 (11%)</p> <p>Bronchodilators, 26 (11%)</p> <p>More than 500 additional treatments were reported by participants</p> <p>Limiting exercise or exertion</p> <p>Quitting alcohol or caffeine</p> <p>Hydration and increasing salt intake</p> <p>Intermittent fasting</p> <p>Conclusions</p> <p>In this study, individuals who reported PVS after covid-19 vaccination had low health status,</p> <p>high symptom burden,</p> <p>and high psychosocial stress,</p> <p>despite trying many treatments.</p> <p>There is a need for continued investigation to understand and treat this condition.</p> <p>Looks like you can join, Kindred study</p> <p>Kindred is a community of patients, working with researchers to power more useful, impactful progress.</p> <p>https://www.kindred.hugo.health/research/listen-study</p> <p>https://kindredapp.hugo.health/auth/login?ref=%2F<br /> Credit to : Dr. John Campbell</p> <p> Please support our Sponsors here :
